PBMC Basics Isolate Like a Pro
Techniques in Cytology – Cytospin: Cytospin Cell Resuspension Solution
In this blog series opening article, I discussed how cytospins could be used to separate cancer cells from non-cancer cells1. This cytology method and subsequent staining of the resultant cells are a key component of diagnosis and screening of diseases such as cancer. The …
Techniques in Cytology – Cytospin: Distinguishing Benign Cells from Malignant Cells
Cytology is a key component in diagnosis and screening of diseases such as cancer. It assesses single cells and clusters of cells from sources such as malignant effusions and peripheral blood. Effusions are fluids that leak from blood and lymph vessels and aggregate in tissues …
Immunology
Tumor Immunotherapy: The mechanism of action of anti-CTLA-4 antibodies requires FcgR-dependant TREG depletion
Ipilimumab is an anti-CTLA-4 antibody used for treatment of metastatic melanoma, one of only two cancer immunotherapeutic drugs approved to date by the FDA. CTLA-4 is a negative regulatory molecule expressed by activated T cells as well as by negative regulatory T cells …
Progranulin Antibodies a Common Link in Vasculitis, Lupus, and RA
Patients with autoimmune rheumatic diseases (ARD) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have a significantly increased risk of developing cardiovascular disease (CVD) and often develop CVD earlier than those without underlying autoimmunity, …
Regenerative Medicine
New Findings in Cell Based Therapy for GBM
ISSCR 2013 Meeting Updates: Is a Cure in Sight for Type 1 Diabetes?
Identification of a new HSC viral transduction enhancer, Vectofusin-1
Reprogramming of old HSCs reverses functional defects associated with aging
Mechanical Properties of 3D Cell Culture Affect Stem Cell Phenotype
Neurology
ISSCR 2013 Meeting Updates: Can Alzheimer’s Disease be modeled in a dish?
Phase 1 Trial: Tolerance To MS Autoantigens Using Peptide-Coupled PBMCs
MAPK Pathway Components: Modulators of Ataxin1 Toxicity in SCA1
Deep Brain Stimulation Shows Increased Cerebral Metabolism in Alzheimer’s Patients
Potential of BDNF in Treating Neurodegenerative Disorders
Oncology
BLOCKADE OF CTLA-4 AND PD-1 ENHANCED TUMOR REGRESSION IN MELANOMA
INTESTINAL BACTERIA LINKED TO LYMPHOMA
Remodeling of the Tumor Extracellular Matrix Activates YAP in Fibroblasts to Produce Cancer Associated Fibroblasts
A NEW MOLECULAR TARGET FOR BREAST CANCER THERAPY
FIRST TARGETED THERAPEUTIC APPROACH FOR CHRONIC LYMPHOCYTIC LEUKEMIA